Compositions, containing an alkyl salicylate and an alkali-metal stearate



Patented Mar. 20, 1934 UNITED STATES PATENT OFFICE SALICYLATE AND STEARATE AN ALKALI-METAL Ferdinand W. Nitardy, Brooklyn, N. Y., assignor to E. R. Squibb & Sons, New York, N. Y., a corporation of New York No Drawing. Application March 31, 1933,

Serial No. 663,853

11 Claims.

This invention relates to compositions containing an alkyl salicylate and an alkali-metal stearate, especially analgesic preparations, in which the former serves as a therapeutic agent and the latter as an excipient.

Alkyl salicylates, on account of their anodyne and stimulant properties, have long been esteemed as topical remedies, and are generally applied in the form of creams. By using alkalimetal stearates as excipients therein, it is possible to confer upon such creams certain desirable qualities, among them that of not soiling garments and other fabrics. In time, however, these preparations, as also other compositions containing an alkyl salicylate and an alkali-metal stearate, undergo certain chemical and physical changespresumably, partial hydrolysis of the alkali-metal stearate causing conversion of the alkyl salicylate into alkali-metal salicylate and alcohol, and separation of stearic acid-as a result of which the originally uniform cream ultimately becomes a curdy mass, with separated aqueous portion, a decidedly unacceptable product.

It is the object of this invention to provide compositions, especially analgesic preparations, containing an alkyl salicylate and an alkali-metal stearate, so constituted as not to undergo such substantial physical and chemical changes.

In the practice of this invention compositions containing an alkyl salicylate and an alkali-metal stearate are stabilized by the addition of a compound selected from the group consisting of the oleates of the alkali metals, ammonium, and substituted ammonium.

Examples Numbers at right indicate respective parts by weight. In each instance, the stearic acid is warmed with a portion of the water until melted, an aqueous solution of the potassium hydroxide is added, and heating and stirring are continued until the reaction is complete; an aqueous solution of the potassium, ammonium, or triethanolamine oleate is added, and then an aqueous solution of the soft soap, if any; the mass is stirred, the remaining water is added, and the mixture is allowed to stand until perfectly smooth and uniform; and finally the methyl salicylate, together with the menthol and eugenol, is incorporated by thorough agitation. These particular compositions are analgesic preparations.

Stearic acid 81 Solution potassium hydroxide 30% 33 Potassium oleate 20 Water 260 Methyl salicylate Menthol 40 Eugenol 10 Stearic acid 42.6 Potassium hydroxide 100% 6.3 Oleic acid- 6.5 Ammonia water 28% 1.5 Soft soap 8 Water Methyl salicylate 30 Menthol l6 Eugenol 4 III Stearic acid 426 Solution potassium hydroxide 42% 150 Triethanolamine oleate 80 Soft soap 80 Water 765 Methyl salicylate 300 Menthol 60 Eugenol 40 Compositions so constituted are stable for an indefinitely long period.

It is to be understood that the foregoing examples are merely illustrative and by no means limitative of the invention, which may be variously otherwise embodied-as with respect to the particular salicylate, stearate, oleate, and other ingredients and the proportions used and procedures followedwithin the scope of the appended claims.

I claim:

1. In a composition containing an alkyl sallcylate and an alkali-metal stearate, a compound selected from the group consisting of the oleates of the alkali metals, ammonium, and substituted ammonium.

2. In a composition containing an alkyl salicylate and an alkali-metal stearate: an alkalimetal oleate.

3. In a composition containing an alkyl salicylate and an alkali-metal stearate, ammonium oleate.

4. In a composition containing an alkyl salicylate and an alkali-metal stearate, a substitutedammonium oleate.

5. In an analgesic preparation containing methyl salicylate and potassium stearate, potassium oleate.

6. In an analgesic preparation containing methyl salicylate and potassium stearate, ammonium oleate.

7. In an analgesic preparation containing methyl salicylate and potassium stearate, triethanolamine oleate.

8. In a composition containing an alkyl salicylate and an alkali-metal stearate, a compound selected from the group consisting of the oleates of the alkali metals, ammonium, and substituted ammonium; the weight proportion of oleate to salicylate and stearate together being greater than 5%.

9. In an analgesic preparation containing methyl salicylate and potassium stearate, potassium oleate; the weight proportion of oleate to salicylate and stearate together being greater than 5%.

10. In an analgesic preparation containing methyl salicylate and potassium stearate, ammonium oleate; the weight proportion of oleate to salicylate and stearate being greater than 5%.

11. In an analgesic preparation containing methyl salicylate and potassium stearate, triethanolamineoleate; the weight proportion of oleate to salicylate and stearate together being greater than 5%.

FERDINAND W. NITARDY. 

